HRID2389725

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID962

Water

H2O

HCID4311764

Sodium borohydride (Na(BH4))

H4BNa

结构：CN(C(=O)OC(C)(C)C)C1CCC(N(Cc2cc(-c3ccc(C(=O)C(F)(F)F)cc3)ccc2F)C(=O)c2sc3ccccc3c2Cl)CC1

HCID59766908

未命名化合物

PRODUCTS

生成物

HCID59766923

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Trifluoroacetophenone (265) (90 mg, 0.13 mmol) was dissolved in EtOH (0.9 mL) with a little DCM. Sodium borohydride (8 mg, 0.21 mmol) was added portionwise and the reaction stirred at RT until complete. H2O (5 mL) was added and the product extracted with EtOAc (2×5 mL). Drying (MgSO4), filtration, reduction in vacuo and chromatography with EtOAc/heptanes gave the title compound.

WORKUP

后处理

extractionthe product extracted with EtOAc (2×5 mL)
customDrying
filtration(MgSO4), filtration, reduction in vacuo and chromatography with EtOAc/heptanes

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5ba0c4a2d4fd44b596cd0973088dfe74
来源数据集: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08273747B2
来源说明: uspto-grants-2012_09

反应 SMILES

[C:1]([O:5][C:6](=[O:48])[N:7]([CH:9]1[CH2:14][CH2:13][CH:12]([N:15]([C:36]([C:38]2[S:42][C:41]3[CH:43]=[CH:44][CH:45]=[CH:46][C:40]=3[C:39]=2[Cl:47])=[O:37])[CH2:16][C:17]2[CH:18]=[C:19]([C:24]3[CH:29]=[CH:28][C:27]([C:30](=[O:35])[C:31]([F:34])([F:33])[F:32])=[CH:26][CH:25]=3)[CH:20]=[CH:21][C:22]=2[F:23])[CH2:11][CH2:10]1)[CH3:8])([CH3:4])([CH3:3])[CH3:2].[BH4-].[Na+].O>CCO.C(Cl)Cl>[C:1]([O:5][C:6](=[O:48])[N:7]([CH:9]1[CH2:14][CH2:13][CH:12]([N:15]([C:36]([C:38]2[S:42][C:41]3[CH:43]=[CH:44][CH:45]=[CH:46][C:40]=3[C:39]=2[Cl:47])=[O:37])[CH2:16][C:17]2[CH:18]=[C:19]([C:24]3[CH:25]=[CH:26][C:27]([CH:30]([OH:35])[C:31]([F:33])([F:32])[F:34])=[CH:28][CH:29]=3)[CH:20]=[CH:21][C:22]=2[F:23])[CH2:11][CH2:10]1)[CH3:8])([CH3:4])([CH3:2])[CH3:3]