HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 59766923, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | (4-{(3-Chloro-benzo[b]thiophene-2-carbonyl)-[4-fluoro-4'-(2,2,2-trifluoro-acetyl)-biphenyl-3-ylmethyl]-amino}-cyclohexyl)-methyl-carbamic acid tert-butyl ester | HCID 59766908 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 59766923 | HCID 59766923 | — |
Reaction Steps
Trifluoroacetophenone (265) (90 mg, 0.13 mmol) was dissolved in EtOH (0.9 mL) with a little DCM. Sodium borohydride (8 mg, 0.21 mmol) was added portionwise and the reaction stirred at RT until complete. H2O (5 mL) was added and the product extracted with EtOAc (2×5 mL). Drying (MgSO4), filtration, reduction in vacuo and chromatography with EtOAc/heptanes gave the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273747B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-5ba0c4a2d4fd44b596cd0973088dfe74 |
| Source note | uspto-grants-2012_09 |