反应详情

16.6 g (51.19 mmol) of 7-(2,4-dichlorophenyl)-5-(ethylthio)imidazo[1,2-c]pyrimidine are dissolved in 330 ml of methanol, and 77 ml of a 2 molar aqueous potassium hydroxide solution are added. The mixture is stirred at the reflux temperature for 2 h. After cooling, 300 ml of water are added and then, while cooling in ice, 140 ml of 0.1 molar hydrochloric acid. The mixture is then neutralized with saturated aqueous ammonium chloride solution and stirred for 10 min, and the solid is filtered off with suction. It is thoroughly washed with water and dried under high vacuum. 13.6 g (92% of theory) of the product are obtained as a solid.

1. temperatureAfter cooling
2. temperaturewhile cooling in ice
3. stirringstirred for 10 min
4. filtrationthe solid is filtered off with suction
5. washIt is thoroughly washed with water
6. customdried under high vacuum
7. custom13.6 g (92% of theory) of the product are obtained as a solid