Trifluoroacetic acid → HCID 86641358, compound

HRID 2389755Notes

Reaction equation

HRID 2389755 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH:9]([CH3:19])[CH2:10][NH:11]C(=O)OC(C)(C)C)[CH:5]=[CH:4][C:3]=1[N+:20]([O-:22])=[O:21].[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26]>ClCCl>[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26].[NH2:11][CH2:10][CH:9]([NH:8][C:6]1[N:7]=[C:2]([NH2:1])[C:3]([N+:20]([O-:22])=[O:21])=[CH:4][CH:5]=1)[CH3:19]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59312926HCID 59312926, compound

Product 1

HCID 86641358HCID 86641358, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

N6-(2-Amino-1-methylethyl)-3-nitropyridine-2,6-diamine trifluoracetate (Example 40A) is prepared in analogy to Example 40A from tert-butyl {2-[(6-amino-5-nitropyridin-2-yl)amino]propyl}carbamate (Example 39A) (560 mg, 1.8 mmol), trifluoroacetic acid (2.0 ml, 27 mmol) in dichloromethane (20 ml). 900 mg of the crude product are obtained thus as a solid.

Sources & evidence

ORD record
ord-4881e003c8964cd496a4e74ecc63be12
Source dataset
uspto-grants-2012_09
Patent number
US08273752B2

Reaction notes

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