HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 68713943, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl {2-[(5-cyanopyridin-2-yl)thio]ethyl}carbamate | HCID 59313027 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 68713943 | HCID 68713943 | — |
Reaction Steps
6-[(2-Aminoethyl)thio]nicotinonitrile trifluoroacetate (Example 45A) is prepared in analogy to Example 40A from tert-butyl {2-[(5-cyanopyridin-2-yl)thio]ethyl}carbamate (Example 42A) (580 mg, 2.1 mmol) and trifluoroacetic acid (3.2 ml, 42 mmol) in dichloromethane (20 ml). 500 mg of the product are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273752B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-7014036ea1c24109b26bc55c94dc9118 |
| Source note | uspto-grants-2012_09 |