反应详情

温度

0 °C

33 g (169.2 mmol) of 4,6-dichloro-2-(methylthio)pyrimidine are introduced into 300 ml of THF at −20° C., and 169 ml of a 1M solution of hydrazine in THF is added dropwise at a rate such that the temperature does not rise above −15° C. The mixture is stirred at 0° C. for a further 2 h. After the reaction is complete, the solvent is distilled off and the residue is stirred with diethyl ether. 18.4 g (57% of theory) of the product are obtained as a solid.

1. customdoes not rise above −15° C
2. distillationthe solvent is distilled off
3. stirringthe residue is stirred with diethyl ether
4. custom18.4 g (57% of theory) of the product are obtained as a solid