Trifluoroacetic acid → HCID 86641362, compound

HRID 2389770Notes

Reaction equation

HRID 2389770 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][CH2:11][NH:12]C(=O)OC(C)(C)C)[CH:5]=[CH:4][C:3]=1[N+:20]([O-:22])=[O:21].[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26]>ClCCl>[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26].[NH2:12][CH2:11][CH2:10][CH2:9][NH:8][C:6]1[N:7]=[C:2]([NH2:1])[C:3]([N+:20]([O-:22])=[O:21])=[CH:4][CH:5]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57911772HCID 57911772, compound

Product 1

HCID 86641362HCID 86641362, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

195 mg (0.56 mmol) of tert-butyl {3-[(6-amino-5-nitropyridin-2-yl)amino]propyl}carbamate (Example 56A) are dissolved in 6 ml of dichloromethane, and 656 mg (5.6 mmol) of trifluoroacetic acid are slowly injected. The mixture is stirred at RT for 16 h and then all the volatile constituents are removed in vacuo. 185 mg (96% of theory) of the product are obtained.

Workup

  1. customall the volatile constituents are removed in vacuo
  2. custom185 mg (96% of theory) of the product are obtained

Sources & evidence

ORD record
ord-cd081b52f98842ca915e5abac0d1de7f
Source dataset
uspto-grants-2012_09
Patent number
US08273752B2

Reaction notes

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