Ethanolamine → HCID 59312971, compound

HRID 2389779Notes

Reaction equation

HRID 2389779 reaction equation
[NH2:1][C:2]1[N:3]=[C:4](S(C)(=O)=O)[S:5][C:6]=1[C:7]#[N:8].[NH2:13][CH2:14][CH2:15][OH:16]>CS(C)=O>[NH2:1][C:2]1[N:3]=[C:4]([NH:13][CH2:14][CH2:15][OH:16])[S:5][C:6]=1[C:7]#[N:8]

Participants

4

Reactant 2

HCID 700EthanolamineHCID 198350775-Thiazolecarbonitrile, 4-amino-2-(methylsulfonyl)-

Product 1

HCID 59312971HCID 59312971, compoundYield 116.8%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Example 89A is prepared in analogy to Example 48A from 4-amino-2-(methylsulphonyl)-1,3-thiazole-5-carbonitrile (Example 18A) (499 mg, 2.45 mmol) and 2-aminoethanol (300 mg, 4.91 mmol) in DMSO (80° C., 20 h). Removal of the solvent results in a crude product 527 mg (50% of theory) which is employed without further purification.

Workup

  1. customRemoval of the solvent

Sources & evidence

ORD record
ord-c30544b2ec40403dbfa88170336bd052
Source dataset
uspto-grants-2012_09
Patent number
US08273752B2

Reaction notes

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