HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanolamine → HCID 59312971, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | 5-Thiazolecarbonitrile, 4-amino-2-(methylsulfonyl)- | HCID 19835077 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 59312971 | HCID 59312971 | 116.8% |
Reaction Steps
Example 89A is prepared in analogy to Example 48A from 4-amino-2-(methylsulphonyl)-1,3-thiazole-5-carbonitrile (Example 18A) (499 mg, 2.45 mmol) and 2-aminoethanol (300 mg, 4.91 mmol) in DMSO (80° C., 20 h). Removal of the solvent results in a crude product 527 mg (50% of theory) which is employed without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273752B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-c30544b2ec40403dbfa88170336bd052 |
| Source note | uspto-grants-2012_09 |