Phosphorus oxychloride → HCID 59313080, compound

HRID 2389783Notes

Reaction equation

HRID 2389783 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[C:13](O)[N:12]2[CH:16]=[C:17]([CH2:19][N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)[N:18]=[C:11]2[CH:10]=1.P(Cl)(Cl)([Cl:28])=O>>[Cl:28][C:13]1[N:12]2[CH:16]=[C:17]([CH2:19][N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)[N:18]=[C:11]2[CH:10]=[C:9]([C:3]2[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=2[Cl:1])[N:14]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178517483HCID 178517483, compound

Product 1

HCID 59313080HCID 59313080, compound

Procedure

103 mg (0.267 mmol) of 7-(2,4-dichlorophenyl)-2-(morpholin-4-ylmethyl)imidazo[1,2-c]-pyrimidin-5-ol (Example 93A) are introduced in 5 ml (53.64 mmol) of phosphoryl chloride and heated at the reflux temperature for 3 h. The mixture is allowed to cool and is added cautiously to an ice/water mixture. The precipitate which separates out is filtered off. Drying under high vacuum results in 105 mg (99% of theory) of the product.

Workup

  1. temperatureheated at the reflux temperature for 3 h
  2. temperatureto cool
  3. filtrationThe precipitate which separates out is filtered off
  4. customDrying under high vacuum
  5. customresults in 105 mg (99% of theory) of the product

Sources & evidence

ORD record
ord-1c6b0b436da1428a9631aad2158a70a9
Source dataset
uspto-grants-2012_09
Patent number
US08273752B2

Reaction notes

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