Phosphorus oxychloride → HCID 59313087, compound

HRID 2389784Notes

Reaction equation

HRID 2389784 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[C:13](O)[N:12]2[CH:16]=[C:17]([CH2:19][N:20]3[CH2:25][CH2:24][N:23]([CH3:26])[CH2:22][CH2:21]3)[N:18]=[C:11]2[CH:10]=1.P(Cl)(Cl)([Cl:29])=O>>[Cl:29][C:13]1[N:12]2[CH:16]=[C:17]([CH2:19][N:20]3[CH2:25][CH2:24][N:23]([CH3:26])[CH2:22][CH2:21]3)[N:18]=[C:11]2[CH:10]=[C:9]([C:3]2[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=2[Cl:1])[N:14]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178480838HCID 178480838, compound

Product 1

HCID 59313087HCID 59313087, compound

Procedure

In analogy to Example 95A, 42 mg (17% of theory) of the product are obtained from 225 mg (0.49 mmol) of 7-(2,4-dichlorophenyl)-2-[(4-methylpiperazin-1-yl)methyl]imidazo[1,2-c]-pyrimidin-5-ol (Example 94A) by reaction with phosphoryl chloride.

Sources & evidence

ORD record
ord-7b296b23dc4344d3bb94841112fa0536
Source dataset
uspto-grants-2012_09
Patent number
US08273752B2

Reaction notes

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