Phosphorus oxychloride → HCID 59312881, compound

HRID 2389786Notes

Reaction equation

[Cl:1][C:2]1[N:7]=[C:6](O)[N:5]2[CH:9]=[C:10]([CH2:12][N:13]([CH3:15])[CH3:14])[N:11]=[C:4]2[CH:3]=1.P(Cl)(Cl)([Cl:18])=O>>[Cl:18][C:6]1[N:5]2[CH:9]=[C:10]([CH2:12][N:13]([CH3:15])[CH3:14])[N:11]=[C:4]2[CH:3]=[C:2]([Cl:1])[N:7]=1

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 178483297HCID 178483297, compound

Product 1

HCID 59312881HCID 59312881, compound

Procedure

In analogy to Example 11A, 30 mg (18% of theory) of the product are obtained from 131 mg (0.58 mmol) of 7-chloro-2-[(dimethylamino)methyl]imidazo[1,2-c]pyrimidin-5-ol (Example 98A) by reaction with phosphoryl chloride.

Sources & evidence

ORD record: ord-651823567cec4e1abb7d7bc3b9e13e4d
Source dataset: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08273752B2

Reaction notes

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