Phosphorus oxychloride → HCID 59312915, compound

HRID 2389788Notes

Reaction equation

HRID 2389788 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](O)[N:5]2[N:9]=[C:10]([CH2:12][CH3:13])[N:11]=[C:4]2[CH:3]=1.P(Cl)(Cl)([Cl:16])=O>>[Cl:16][C:6]1[N:5]2[N:9]=[C:10]([CH2:12][CH3:13])[N:11]=[C:4]2[CH:3]=[C:2]([Cl:1])[N:7]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178437473HCID 178437473, compound

Product 1

HCID 59312915HCID 59312915, compound

Procedure

In analogy to Example 11A, 285 mg (80% of theory) of the product are obtained from 312 mg (1.57 mmol) of 7-chloro-2-ethyl[1,2,4]triazolo[1,5-c]pyrimidin-5-ol (Example 102A) by reaction with phosphoryl chloride.

Sources & evidence

ORD record
ord-0766931e494f4cc3bdc92b717577597e
Source dataset
uspto-grants-2012_09
Patent number
US08273752B2

Reaction notes

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