HCID 68950348, compound → HCID 86636899, compound

HRID 238979Notes

Reaction equation

HRID 238979 reaction equation
[Cl:1][C:2]1[CH:33]=[CH:32][C:5]2[S:6][C:7]([S:10]([N:13]([C:15]3[CH:20]=[CH:19][C:18]([CH:21]4[CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22]4)=[CH:17][CH:16]=3)[CH3:14])(=[O:12])=[O:11])=[C:8]([CH3:9])[C:4]=2[CH:3]=1>C(O)=O>[NH:23]1[CH2:24][CH:21]([C:18]2[CH:19]=[CH:20][C:15]([N:13]([CH3:14])[S:10]([C:7]3[S:6][C:5]4[CH:32]=[CH:33][C:2]([Cl:1])=[CH:3][C:4]=4[C:8]=3[CH3:9])(=[O:12])=[O:11])=[CH:16][CH:17]=2)[CH2:22]1

Participants

3

Reactant 1

HCID 68950348HCID 68950348, compound

Product 1

HCID 86636899HCID 86636899, compoundYield 98.3%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

tert-Butyl 3-(4-(5-chloro-N,3-dimethylbenzo[b]thiophene-2-sulfonamido)phenyl)azetidine-1-carboxylate (185 mg, 0.36 mmol) was stirred in formic acid (3 ml) at 0° C. for 3.5 h. The solution was concentrated, dissolved in water, concentrated HCl was added and the solution was concentrated by lyophylisation to give the title compound (144 mg, 87%) as a white foam.

Workup

  1. concentrationThe solution was concentrated
  2. dissolutiondissolved in water
  3. additionconcentrated HCl was added
  4. concentrationthe solution was concentrated by lyophylisation

Sources & evidence

ORD record
ord-c8e511857d094658a3f9303843986ccf
Source dataset
uspto-grants-2014_02
Patent number
US08642642B2

Reaction notes

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