2-Thiophenesulfonyl chloride → Thiophene-2-sulfonic acid [4-(1-propyl-azetidin-3-yl)-phenyl]-amide

HRID 238981Notes

Reaction equation

HRID 238981 reaction equation
[CH2:1]([N:4]1[CH2:7][CH:6]([C:8]2[CH:14]=[CH:13][C:11]([NH2:12])=[CH:10][CH:9]=2)[CH2:5]1)[CH2:2][CH3:3].[S:15]1[CH:19]=[CH:18][CH:17]=[C:16]1[S:20](Cl)(=[O:22])=[O:21]>>[CH2:1]([N:4]1[CH2:5][CH:6]([C:8]2[CH:9]=[CH:10][C:11]([NH:12][S:20]([C:16]3[S:15][CH:19]=[CH:18][CH:17]=3)(=[O:22])=[O:21])=[CH:13][CH:14]=2)[CH2:7]1)[CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 855182-Thiophenesulfonyl chlorideHCID 57470084HCID 57470084, compound

Product 1

HCID 86636901Thiophene-2-sulfonic acid [4-(1-propyl-azetidin-3-yl)-phenyl]-amide

Procedure

Following the same procedure as described in Example 1.7, 4-(1-propylazetidin-3-yl)aniline was coupled with thiophene-2-sulfonyl chloride to give the title compound.

Sources & evidence

ORD record
ord-d8581e0d055041bfb8a9a88cd860e856
Source dataset
uspto-grants-2014_02
Patent number
US08642642B2

Reaction notes

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