Phosphorus oxychloride → HCID 59312894, compound

HRID 2389819Notes

Reaction equation

HRID 2389819 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[C:13](O)[N:12]2[N:16]=[C:17]([CH3:19])[N:18]=[C:11]2[CH:10]=1.P(Cl)(Cl)([Cl:22])=O>[Cl-].C([N+](CC)(CC)CC)C1C=CC=CC=1>[Cl:22][C:13]1[N:12]2[N:16]=[C:17]([CH3:19])[N:18]=[C:11]2[CH:10]=[C:9]([C:3]2[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=2[Cl:1])[N:14]=1

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178432078HCID 178432078, compound

Product 1

HCID 59312894HCID 59312894, compound

Reagents, catalysts & solvents 1

HCID 66133Benzyl triethylammonium chlorideCatalyst

Procedure

In analogy to Example 53A, 676 mg (49% of theory) of the product are obtained from 685 mg (2.31 mmol) of 7-(2,4-dichlorophenyl)-2-methyl[1,2,4]triazolo[1,5-c]pyrimidin-5-ol (Example 136A) by reaction in 6 ml of phosphoryl chloride and 1.59 g (6.96 mmol) of benzyltriethylammonium chloride.

Sources & evidence

ORD record
ord-8ba360f0e8c94c96934c8748df822a65
Source dataset
uspto-grants-2012_09
Patent number
US08273752B2

Reaction notes

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