Propylamine → HCID 60205205, compound

HRID 238982Notes

Reaction equation

HRID 238982 reaction equation
CS(O[CH2:6][C@H:7]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[CH2:8][CH2:9]OS(C)(=O)=O)(=O)=O.[CH2:21]([NH2:24])[CH2:22][CH3:23]>C(OCC)C>[C:15]1([C@@H:7]2[CH2:8][CH2:9][N:24]([CH2:21][CH2:22][CH3:23])[CH2:6]2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 7852PropylamineHCID 57470068HCID 57470068, compound

Product 1

HCID 60205205HCID 60205205, compoundYield 104.5%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

2.0 g of methanesulfonic acid (S)-4-methanesulfonyloxy-3-phenyl-butyl ester (5.51 mmol) were dissolved in 5 ml of n-propylamine (60.82 mmol). The reaction mixture was stirred for 15 h at room temperature, diethyl ether added, the organic phase washed twice with water. The aqueous phase was reextracted once with diethylether, the organic layers combined, dried over magnesium sulfate, filtered, and the solvent evaporated under reduced pressure to yield 1.09 g of the product. ESI-MS: 190.1 [M+H]+

Workup

  1. washthe organic phase washed twice with water
  2. dry with materialdried over magnesium sulfate
  3. filtrationfiltered
  4. customthe solvent evaporated under reduced pressure

Sources & evidence

ORD record
ord-b53a2163bd844c27bbb598c4a73d4a54
Source dataset
uspto-grants-2014_02
Patent number
US08642642B2

Reaction notes

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