Chlorosulfonic acid → 5-(Trifluoromethyl)thiophene-2-sulfonyl chloride

HRID 238985Notes

Reaction equation

HRID 238985 reaction equation
[F:1][C:2]([F:9])([F:8])[C:3]1[S:4][CH:5]=[CH:6][CH:7]=1.[Cl:10][S:11](O)(=[O:13])=[O:12].S(Cl)(Cl)(=O)=O>ClCCl>[F:1][C:2]([F:9])([F:8])[C:3]1[S:4][C:5]([S:11]([Cl:10])(=[O:13])=[O:12])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 24638Chlorosulfonic acidHCID 24648Sulfuryl chlorideHCID 27607852-(Trifluoromethyl)thiophene

Product 1

HCID 866369025-(Trifluoromethyl)thiophene-2-sulfonyl chloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

5-trifluoromethyl-thiophene-2-sulfonylchloride was prepared from commercially available 2-trifluoromethyl-thiophene through reaction with chlorosulfonic acid in dichloromethane and subsequent silica gel chromatography (1H-NMR of the sulfonylchloride (CDCl3, 400 MHz): δ [ppm] 7.9 (1H, d), 7.5 (1H, d)).

Sources & evidence

ORD record
ord-fe286bc1a5b44332b6db904d905b1c9b
Source dataset
uspto-grants-2014_02
Patent number
US08642642B2

Reaction notes

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