HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorosulfonic acid → 5-(Trifluoromethyl)thiophene-2-sulfonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorosulfonic acid | HCID 24638 | — |
| Reactant | Sulfuryl chloride | HCID 24648 | — |
| Reactant | 2-(Trifluoromethyl)thiophene | HCID 2760785 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-(Trifluoromethyl)thiophene-2-sulfonyl chloride | HCID 86636902 | — |
Reaction Steps
5-trifluoromethyl-thiophene-2-sulfonylchloride was prepared from commercially available 2-trifluoromethyl-thiophene through reaction with chlorosulfonic acid in dichloromethane and subsequent silica gel chromatography (1H-NMR of the sulfonylchloride (CDCl3, 400 MHz): δ [ppm] 7.9 (1H, d), 7.5 (1H, d)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642642B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-fe286bc1a5b44332b6db904d905b1c9b |
| Source note | uspto-grants-2014_02 |