Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanolamine → HCID 49785857, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanolamine | HCID 700 | — |
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Isatin | HCID 7054 | — |
| 반응물 | 6-Chloro-11H-indolo[3,2-c]quinoline | HCID 5410307 | — |
| 용매 | Glycol monoethyl ether | HCID 8076 | — |
| 생성물 | HCID 49785857 | HCID 49785857 | 61% |
반응 단계
A mixture of compound 4a as obtained from the above Synthesis Ex. 1 (0.50 g, 2 mmol) and 2-aminoethanol (0.24 g, 4 mmol) in 2-ethoxyethanol (20 mL) was heated at 140-150° C. for 48 hrs (by TLC monitoring). After cooling, the reaction mixture was evaporated in vacuo to give a residue, which was treated with MeOH (30 mL) to result in precipitation. The resultant precipitate was collected by filtration and recrystallized with MeOH to give the title compound 7d as a white powder (0.38 g, 61% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08273760B2 |
| 출처 데이터셋 | uspto-grants-2012_09 |
| ORD ID | ord-60acdee8c7cb47a29c3076f9021f1857 |
| 출처 메모 | uspto-grants-2012_09 |