反应详情

A mixture of compound 4a as obtained from the above Synthesis Ex. 1 (0.50 g, 2 mmol) and 2-aminoethanol (0.24 g, 4 mmol) in 2-ethoxyethanol (20 mL) was heated at 140-150° C. for 48 hrs (by TLC monitoring). After cooling, the reaction mixture was evaporated in vacuo to give a residue, which was treated with MeOH (30 mL) to result in precipitation. The resultant precipitate was collected by filtration and recrystallized with MeOH to give the title compound 7d as a white powder (0.38 g, 61% yield).

1. customas obtained from the above Synthesis Ex
2. temperatureAfter cooling
3. customthe reaction mixture was evaporated in vacuo
4. customto give a residue, which
5. customto result in precipitation
6. filtrationThe resultant precipitate was collected by filtration
7. customrecrystallized with MeOH