HCID 53308978, compound → 2-(2-Ethyl-8,9-dihydrofuro[3,2-c]pyrazolo[1,5-a]pyridin-1-yl)ethanamine

HRID 2389887Notes

Reaction equation

HRID 2389887 reaction equation
[CH2:1]([C:3]1[C:14]([CH2:15][C:16]#[N:17])=[C:6]2[C:7]3[CH2:13][CH2:12][O:11][C:8]=3[CH:9]=[CH:10][N:5]2[N:4]=1)[CH3:2]>N.CO.[Co]>[CH2:1]([C:3]1[C:14]([CH2:15][CH2:16][NH2:17])=[C:6]2[C:7]3[CH2:13][CH2:12][O:11][C:8]=3[CH:9]=[CH:10][N:5]2[N:4]=1)[CH3:2]

Participants

4

Reactant 1

HCID 53308978HCID 53308978, compound

Product 1

HCID 533089832-(2-Ethyl-8,9-dihydrofuro[3,2-c]pyrazolo[1,5-a]pyridin-1-yl)ethanamineYield 98.3%

Reagents, catalysts & solvents 2

HCID 104730CobaltCatalystHCID 21705897Ammonia methanolSolvent

Procedure

(2-Ethyl-8,9-dihydrofuro[3,2-c]pyrazolo[1,5-a]pyridin-1-yl)acetonitrile (120 mg, 0.528 mmol) and Raney cobalt (1.2 g) were suspended in 2M ammonia/methanol solution (25 mL), and the suspension was stirred at room temperature for 12 hr under a hydrogen atmosphere. The catalyst was filtered through celite, and the filtrate was concentrated under reduced pressure to give the title compound (120 mg, yield 98%).

Workup

  1. filtrationThe catalyst was filtered through celite
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-51c3d1c54d1247e0bccd10ed11ef149e
Source dataset
uspto-grants-2012_09
Patent number
US08273761B2

Reaction notes

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