反应详情

1.68 g of (2R,4S)-2-Methyl-4-phenyl-pyrrolidine-1-carboxylic acid tert-butyl ester (6.42 mmol) were dissolved in 40 ml dichloromethane and 19.2 ml (38.56 mmol) 2N HCl in diethylether dropwise added. After stirring at room temperature for 16 h, the solvents were evaporated, the residue was dissolved in water, the pH was adjusted to pH 9 with aqueous sodium hydroxide, and the aqueous phase was extracted three times with ethyl acetate. The organic phases were combined, dried over magnesium sulphate, filtered and evaporated to dryness under reduced pressure to yield 1.05 g of product.

1. customthe solvents were evaporated
2. dissolutionthe residue was dissolved in water
3. extractionthe aqueous phase was extracted three times with ethyl acetate
4. dry with materialdried over magnesium sulphate
5. filtrationfiltered
6. customevaporated to dryness under reduced pressure