HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2389916Generated: November 1, 2026
(2E)-1,2,6,7-tetrahydro-8H-cyclopenta[b]furo[3,2-d]pyridin-8-ylideneacetonitrile → (2E)-2-(1,2,6,7-tetrahydro-8H-cyclopenta[b]furo[3,2-d]pyridin-8-ylidene)ethanamine
https://huagongshe.com/reaction/2389916
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | (2E)-1,2,6,7-tetrahydro-8H-cyclopenta[b]furo[3,2-d]pyridin-8-ylideneacetonitrile | HCID 59179421 | — |
| Catalyst | Cobalt | HCID 104730 | — |
| Solvent | Ethanol, reaction products with ammonia, distn. residues | HCID 22020343 | — |
| Product | (2E)-2-(1,2,6,7-tetrahydro-8H-cyclopenta[b]furo[3,2-d]pyridin-8-ylidene)ethanamine | HCID 59179360 | 99% |
Reaction Steps
A suspension of (2E)-1,2,6,7-tetrahydro-8H-cyclopenta[b]furo[3,2-d]pyridin-8-ylideneacetonitrile (10.0 mg, 0.054 mmol) and Raney cobalt (100 mg) in 2M ammonia/ethanol (1 mL) was stirred at 50° C. for 3 hr under a hydrogen atmosphere. The catalyst was filtered through celite, and the filtrate was concentrated under reduced pressure to give the title compound (10.0 mg, yield 99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08273761B2 |
|---|
| Source dataset | uspto-grants-2012_09 |
|---|
| ORD ID | ord-5b1d6f6d68b242f8a1f510c170d54879 |
|---|
| Source note | uspto-grants-2012_09 |
|---|
