HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 239001Generated: October 25, 2026
Hydrochloric Acid → Erlotinib Hydrochloride
https://huagongshe.com/reaction/239001
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Benzenamine, 3-ethynyl- | HCID 104682 | — |
| Reactant | 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline | HCID 11289942 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Erlotinib Hydrochloride | HCID 176871 | 91.9% |
Reaction Steps
1.98 Kg of 4-chloro-6,7-bis (2-methoxyethoxy) quinazoline was suspended in 30 litres of acetonitrile and 10 litres of toluene and 1.0 Kg of 3-aminophenyl acetylene was charged at 25-30° C. and hydrochloric acid was added. The reaction mass was heated and stirred at 35-40° C. for 6 hours. The solid obtained was filtered and washed with a mixture of acetonitrile and toluene. The product was dried at 38-40° C. to obtain 2.5 Kg of erlotinib hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08642758B2 |
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| Source dataset | uspto-grants-2014_02 |
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| ORD ID | ord-6027599214704f5aafedec897e1eb7d8 |
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| Source note | uspto-grants-2014_02 |
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