反应详情

66 mg of 3-benzoyl-2-benzyl-6-fluoro-1,2,3,4-tetrahydroisoquinoline and 30 mg of 10% Pd—C were dissolved in 2 mL of ethanol and 2 mL of 4N hydrochloric acid, followed by stirring at room temperature for 48 hours under a hydrogen atmosphere. The reaction liquid was filtered through Celite, and the filtrate was concentrated under reduced pressure, and the residue obtained was purified using silica gel chromatography (chloroform:methanol=5:1) to obtain 8 mg (yield 18%) of a title compound as a yellow oily substance.

1. customThe reaction liquid
2. filtrationwas filtered through Celite
3. concentrationthe filtrate was concentrated under reduced pressure
4. customthe residue obtained
5. customwas purified