反应详情

A solution of 3-bromo-4-hydroxybenzonitrile (Lancaster; 3.00 g; 15.2 mmol) in acetone (30 mL) was treated with potassium carbonate (2.30 g; 16.7 mmol), stirred for 10 minutes then treated with tert-butyl bromoacetate (2.24 mL; 15.2 mmol). The reaction mixture was stirred at 65° C. for 18 hours, then the mixture was filtered, the solid was washed with acetone and the filtrate was concentrated to dryness under vacuum to give the title compound as a yellow sticky solid (4.75 g, quant).

1. stirringThe reaction mixture was stirred at 65° C. for 18 hours
2. filtrationthe mixture was filtered
3. washthe solid was washed with acetone
4. concentrationthe filtrate was concentrated to dryness under vacuum