反应详情

A cooled (0° C.) solution of 5-bromopyridine-3-sulfonyl chloride hydrochloride (3.00 g, 10.2 mmol) in DCM (50 ml) was slowly treated with triethylamine (4.3 ml) and stirred until a clear solution was obtained. This solution was treated dropwise with 2-hydroxyethylamine (0.68 g, 0.68 mL) and stirred at RT for 16 hours. The reaction mixture was washed successively with water and brine, the organic layer was dried with sodium sulfate and evaporated under reduced pressure. The crude product was purified by column chromatography (silica) eluting with 20% ethyl acetate in petroleum ether, to give the title compound.

1. customwas obtained
2. stirringstirred at RT for 16 hours
3. washThe reaction mixture was washed successively with water and brine
4. dry with materialthe organic layer was dried with sodium sulfate
5. customevaporated under reduced pressure
6. customThe crude product was purified by column chromatography (silica)
7. washeluting with 20% ethyl acetate in petroleum ether