tert-Butyl bromoacetate → Tert-butyl (2-bromo-4-trifluoromethylphenoxy)acetate

HRID 2390146Notes

Reaction equation

HRID 2390146 reaction equation
[C:1]([O:5][C:6](=[O:17])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12](Cl)=[CH:11][C:10]=1[Br:16])([CH3:4])([CH3:3])[CH3:2].BrC1C=C([C:25]([F:28])([F:27])[F:26])C=CC=1O.BrCC(OC(C)(C)C)=O>>[C:1]([O:5][C:6](=[O:17])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:25]([F:28])([F:27])[F:26])=[CH:11][C:10]=1[Br:16])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 79177tert-Butyl bromoacetateHCID 27611682-Bromo-4-(trifluoromethyl)phenolHCID 49766393tert-Butyl (2-bromo-4-chlorophenoxy)acetate

Product 1

HCID 58297405Tert-butyl (2-bromo-4-trifluoromethylphenoxy)acetate

Procedure

Following the general method as outlined in Intermediate 1, starting from 2-bromo-4-(trifluoromethyl)phenol and tert-butyl bromoacetate (Aldrich), the title compound was obtained as a dark orange sticky solid in quantitative yield.

Sources & evidence

ORD record
ord-7c743510e981458c86050c046a9f8794
Source dataset
uspto-grants-2012_09
Patent number
US08273769B2

Reaction notes

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