5-(methylsulfonyl)-2-[(1E)-prop-1-en-1-yl]aniline → 5-(Methylsulfonyl)-2-propylaniline

HRID 2390157Notes

Reaction equation

HRID 2390157 reaction equation
[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8](/[CH:12]=[CH:13]/[CH3:14])=[C:9]([CH:11]=1)[NH2:10])(=[O:4])=[O:3].[H][H]>CO.[Pd]>[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([CH2:12][CH2:13][CH3:14])=[C:9]([CH:11]=1)[NH2:10])(=[O:3])=[O:4]

Participants

5

Reactant 2

HCID 585220135-(methylsulfonyl)-2-[(1E)-prop-1-en-1-yl]aniline2×HCID 178418361HCID 178418361, compound

Product 1

HCID 585220065-(Methylsulfonyl)-2-propylaniline

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 5-(methylsulfonyl)-2-[(1E)-prop-1-en-1-yl]aniline (Intermediate 60; 1.50 g; 6.84 mmol) and 10% Pd/C (196 mg) in MeOH (39 ml) was placed in a PARR reactor and treated with a pressure of 20 atm of hydrogen for 3 hours.

Workup

  1. customwas placed in a PARR reactor

Sources & evidence

ORD record
ord-a332f15c61344e31811bb892ece5d3f9
Source dataset
uspto-grants-2012_09
Patent number
US08273769B2

Reaction notes

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