HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 2-Bromo-4-(isopropylsulfonyl)-1-methylbenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Potassium hydroxy sulfite | HCID 23707502 | — |
| Reactant | 2-Bromo-4-(isopropylthio)-1-methylbenzene | HCID 58521883 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-Bromo-4-(isopropylsulfonyl)-1-methylbenzene | HCID 58522059 | 92% |
Reaction Steps
A cooled (0° C.) solution of 2-bromo-4-(isopropylthio)-1-methylbenzene (123 mg) in THF (10 ml) was treated with a solution of oxone (580 mg) in water (6 ml). The reaction mixture was stirred at RT for 16 hours. The reaction mixture was diluted with ethyl acetate and washed with water. The organic layer was dried over sodium sulfate and concentrated to give the title compound (120 mg, 92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273769B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-2cddf8cfcee24c709daf6588306fcb07 |
| Source note | uspto-grants-2012_09 |