2-Bromo-6-methylpyridin-3-ol → Tert-butyl 2-[(2-bromo-6-methyl-3-pyridinyl)oxy]acetate

HRID 2390170Notes

Reaction equation

HRID 2390170 reaction equation
[C:1]([O:5][C:6](=[O:17])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12](Cl)=[CH:11][C:10]=1[Br:16])([CH3:4])([CH3:3])[CH3:2].BrC1C(O)=CC=C(C)[N:20]=1>>[C:1]([O:5][C:6](=[O:17])[CH2:7][O:8][C:9]1[C:10]([Br:16])=[N:20][C:12]([CH3:11])=[CH:13][CH:14]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 119591012-Bromo-6-methylpyridin-3-olHCID 49766393tert-Butyl (2-bromo-4-chlorophenoxy)acetate

Product 1

HCID 58522063Tert-butyl 2-[(2-bromo-6-methyl-3-pyridinyl)oxy]acetateYield 79%

Procedure

Following the general method as outlined in Intermediate 1, starting from 2-Bromo-6-methylpyridin-3-ol (Activate Scientific), the title compound was obtained in 79% yield as a yellow liquid after purification by flash column chromatography (silica), eluting with chloroform and methanol (98:2).

Sources & evidence

ORD record
ord-25ade33699ab498f90109234595a8ecc
Source dataset
uspto-grants-2012_09
Patent number
US08273769B2

Reaction notes

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