反应详情

Following the general method as outlined in Intermediate 107, starting from (4-chloro-2-ethynyl-phenoxy)-acetic acid tert-butyl ester (Intermediate 3) and 1-bromo-4-fluoro-5-methanesulfonyl-2-methyl-benzene (Ger. Offen. 2000; DE 19919349), the title compound was obtained as a brown oil after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.