HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-4-fluoro-5-methanesulfonyl-2-methyl-benzene → Tert-butyl(4-chloro-2-{[4-fluoro-2-methyl-5-(methylsulfonyl)phenyl]ethynyl}phenoxy)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-4-fluoro-5-methanesulfonyl-2-methyl-benzene | HCID 9838224 | — |
| Reactant | Tert-butyl(4-chloro-2-ethynylphenoxy)acetate | HCID 56594381 | — |
| Reactant | {[2-Fluoro-5-(propylsulfonyl)phenyl]ethynyl}trimethyl silane | HCID 58521874 | — |
| Product | Tert-butyl(4-chloro-2-{[4-fluoro-2-methyl-5-(methylsulfonyl)phenyl]ethynyl}phenoxy)acetate | HCID 58522074 | — |
Reaction Steps
Following the general method as outlined in Intermediate 107, starting from (4-chloro-2-ethynyl-phenoxy)-acetic acid tert-butyl ester (Intermediate 3) and 1-bromo-4-fluoro-5-methanesulfonyl-2-methyl-benzene (Ger. Offen. 2000; DE 19919349), the title compound was obtained as a brown oil after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273769B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-f85a2046f8ef4862893fad11c5f2c6c5 |
| Source note | uspto-grants-2012_09 |