4-Bromo-2-iodophenol → Tert-butyl (4-bromo-2-iodophenoxy)acetate

HRID 2390246Notes

Reaction equation

HRID 2390246 reaction equation
[C:1]([O:5][C:6](=[O:17])[CH2:7]OC1C=CC(Cl)=CC=1Br)([CH3:4])([CH3:3])[CH3:2].[Br:18][C:19]1[CH:24]=[CH:23][C:22]([OH:25])=[C:21]([I:26])[CH:20]=1>>[Br:18][C:19]1[CH:24]=[CH:23][C:22]([O:25][CH2:7][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:17])=[C:21]([I:26])[CH:20]=1

Participants

3

Reactant 2

HCID 109245324-Bromo-2-iodophenol2×HCID 49766393tert-Butyl (2-bromo-4-chlorophenoxy)acetate

Product 1

HCID 56593849Tert-butyl (4-bromo-2-iodophenoxy)acetate

Procedure

Following the general method as outlined in Intermediate 1, starting from 4-bromo-2-iodophenol (Intermediate 189), the title compound was obtained as a brown oil after purification by flash column chromatography (silica), eluting with 2% methanol in chloroform.

Sources & evidence

ORD record
ord-f143b0730e7f4d42a2d6327169e65112
Source dataset
uspto-grants-2012_09
Patent number
US08273769B2

Reaction notes

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