Tert-butyl (4-bromo-2-iodophenoxy)acetate → Tert-butyl(4-bromo-2-{[3-(propylsulfonyl)phenyl]ethynyl}phenoxy)acetate

Participants

Reaction Steps

Following the general method as outlined in Intermediate 20, starting from (4-bromo-2-iodo-phenoxy)-acetic acid tert-butyl ester (Intermediate 190) and 1-ethynyl-3-(propane-1-sulfonyl)-benzene (Intermediate 42), the title compound was obtained as a yellow sticky solid after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.

Provenance & Evidence