HRID2390250

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11171100

1,3,5-Trimethylpyrazole-4-boronic acid

C6H11BN2O2

结构：CCCS(=O)(=O)c1cccc(C#Cc2cc(Br)ccc2OCC(=O)OC(C)(C)C)c1

HCID56593972

未命名化合物

2 次

PRODUCTS

生成物

结构：CCCS(=O)(=O)c1cccc(C#Cc2cc(-c3c(C)nn(C)c3C)ccc2OCC(=O)OC(C)(C)C)c1

HCID58521894

未命名化合物

PROCEDURE

实验过程

Following the general method as outlined in Intermediate 192, starting from tert-butyl(4-bromo-2-{[3-(propylsulfonyl)phenyl]ethynyl}phenoxy)acetate (Intermediate 191) and 1,3,5-trimethyl-1H-pyrazole-4-boronic acid, pinacol ester, the title compound was obtained as a black sticky solid after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.