1,3,5-Trimethylpyrazole-4-boronic acid → tert-butyl[2-{[3-(propylsulfonyl)phenyl]ethynyl}-4-(1,3,5-trimethyl-1H-pyrazol-4-yl)phenoxy]acetate

Participants

Reaction Steps

Following the general method as outlined in Intermediate 192, starting from tert-butyl(4-bromo-2-{[3-(propylsulfonyl)phenyl]ethynyl}phenoxy)acetate (Intermediate 191) and 1,3,5-trimethyl-1H-pyrazole-4-boronic acid, pinacol ester, the title compound was obtained as a black sticky solid after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.

Provenance & Evidence