Dimethylamine → HCID 58522027, compound

HRID 2390304Notes

Reaction equation

HRID 2390304 reaction equation
[Br:1][C:2]1[CH:15]=[CH:14][C:5]([C:6]([N:8]([CH2:10]CCC)[CH3:9])=[O:7])=[C:4]([S:16]([CH:19]([CH3:21])[CH3:20])(=[O:18])=[O:17])[CH:3]=1.BrC1C=CC(C(O)=O)=C(S(C(C)C)(=O)=O)C=1.CNC>>[Br:1][C:2]1[CH:15]=[CH:14][C:5]([C:6]([N:8]([CH3:10])[CH3:9])=[O:7])=[C:4]([S:16]([CH:19]([CH3:21])[CH3:20])(=[O:18])=[O:17])[CH:3]=1

Participants

4

Reactant 3

HCID 674DimethylamineHCID 56594115HCID 56594115, compound2×HCID 58521909HCID 58521909, compound

Product 1

HCID 58522027HCID 58522027, compound

Procedure

Following the general method as outlined in Intermediate 253, starting from 4-bromo-2-(isopropylsulfonyl)benzoic acid (Intermediate 242) and dimethylamine, the title compound was obtained as a pink solid after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.

Sources & evidence

ORD record
ord-79a4435221c54fa48ffca39cf966f486
Source dataset
uspto-grants-2012_09
Patent number
US08273769B2

Reaction notes

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