反应详情

A mixture of 2-bromo-4-chlorophenol (250 mg; 1.21 mmol) and methyl-2-bromopropionate (VWR; 135 μL, 1.21 mmol) in DME (5 mL) was treated with K2CO3 (250 mg, 1.81 mmol) and refluxed for 18 hours. The reaction mixture was filtered, the filtrate was concentrated and purified by flash column chromatography (silica), eluting with heptane containing increasing amounts of EtOAc. The title compound was obtained as a yellow liquid (306 mg; 87%).

1. temperaturerefluxed for 18 hours
2. filtrationThe reaction mixture was filtered
3. concentrationthe filtrate was concentrated
4. custompurified by flash column chromatography (silica)
5. washeluting with heptane containing
6. temperatureincreasing amounts of EtOAc