反应详情

A solution of 2-bromo-4-chlorophenol (3.00 g; 14.5 mmol) in DCM (20 ml) was treated with chloromethyl methyl ether (1.3 ml; 17 mmol) DIEA (3.3 ml; 19 mmol) for 18 hours. The solvents were evaporated, the residue was taken up in EtOAc, washed with sat. NH4Cl solution and brine, dried over MgSO4, filtered and the solvent removed under reduced pressure to afford the title compound as a colorless oil (3.27 g, 90%).

1. customThe solvents were evaporated
2. washwashed with sat. NH4Cl solution and brine
3. dry with materialdried over MgSO4
4. filtrationfiltered
5. customthe solvent removed under reduced pressure