HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-4-chloro-1-(methoxymethoxy)benzene → 3-{[5-Chloro-2-(methoxymethoxy)phenyl]ethynyl}-4-methylphenyl propyl sulfone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-4-chloro-1-(methoxymethoxy)benzene | HCID 10705921 | — |
| Reactant | Tert-butyl[(3-bromo-5-chloropyridin-2-yl)oxy]acetate | HCID 58521889 | — |
| Reactant | 2-Ethynyl-1-methyl-4-(propylsulfonyl) benzene | HCID 58522033 | — |
| Product | 3-{[5-Chloro-2-(methoxymethoxy)phenyl]ethynyl}-4-methylphenyl propyl sulfone | HCID 58522094 | 70% |
Reaction Steps
Following the general method as outlined in Intermediate 183, starting from 2-bromo-4-chloro-1-(methoxymethoxy)benzene (Intermediate 265) and 2-ethynyl-1-methyl-4-(propane-1-sulfonyl)-benzene (Intermediate 40), the title compound was obtained as a white solid in 70% yield after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273769B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-703f9c735a434ab3bc5bd5cfe22e73ff |
| Source note | uspto-grants-2012_09 |