Benzene, 1-chloro-4-ethynyl- → HCID 46865760, compound

HRID 2390321Notes

Reaction equation

HRID 2390321 reaction equation
C([O:5][C:6](=[O:17])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1Br)(C)(C)C.[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]#[CH:26])=[CH:21][CH:20]=1>>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:6]([OH:5])=[O:17])=[C:10]([C:26]#[C:25][C:22]2[CH:23]=[CH:24][C:19]([Cl:18])=[CH:20][CH:21]=2)[CH:11]=1

Participants

3

Reactant 2

HCID 70118Benzene, 1-chloro-4-ethynyl-HCID 49766393tert-Butyl (2-bromo-4-chlorophenoxy)acetate2×

Product 1

HCID 46865760HCID 46865760, compound

Procedure

Following the general method as outlined in Example 1, starting from tert-butyl(2-bromo-4-chlorophenoxy)acetate (Intermediate 1) and 4-chlorophenylacetylene (Apollo), the title compound was obtained as a beige solid after purification by preparative HPLC

Sources & evidence

ORD record
ord-41a7c15dc3ff47a5b2f252a6f2119ec5
Source dataset
uspto-grants-2012_09
Patent number
US08273769B2

Reaction notes

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