1-Chloro-3-ethynylbenzene → HCID 46865762, compound

HRID 2390322Notes

Reaction equation

HRID 2390322 reaction equation
C([O:5][C:6](=[O:17])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1Br)(C)(C)C.[Cl:18][C:19]1[CH:20]=[C:21]([C:25]#[CH:26])[CH:22]=[CH:23][CH:24]=1>>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:6]([OH:5])=[O:17])=[C:10]([C:26]#[C:25][C:21]2[CH:22]=[CH:23][CH:24]=[C:19]([Cl:18])[CH:20]=2)[CH:11]=1

Participants

3

Reactant 2

HCID 1230861-Chloro-3-ethynylbenzeneHCID 49766393tert-Butyl (2-bromo-4-chlorophenoxy)acetate2×

Product 1

HCID 46865762HCID 46865762, compound

Procedure

Following the general method as outlined in Example 1, starting from tert-butyl(2-bromo-4-chlorophenoxy)acetate (Intermediate 1) and 3-chloro-1-ethynylbenzene (Aldrich), the title compound was obtained as a brown solid after purification by preparative HPLC.

Sources & evidence

ORD record
ord-ec11ec7c15c94e9f87a23dee48a6f2fa
Source dataset
uspto-grants-2012_09
Patent number
US08273769B2

Reaction notes

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