2-Bromopyridine → HCID 46865873, compound

HRID 2390329Notes

Reaction equation

C([O:5][C:6](=[O:18])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[C:16]#[CH:17])(C)(C)C.Br[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=1>>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:6]([OH:5])=[O:18])=[C:10]([C:16]#[C:17][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=2)[CH:11]=1

Participants

Reactant 2

HCID 79732-Bromopyridine

HCID 56594381Tert-butyl(4-chloro-2-ethynylphenoxy)acetate2×

Product 1

HCID 46865873HCID 46865873, compound

Procedure

Following the general method as outlined in Example 10, starting from tert-butyl(4-chloro-2-ethynylphenoxy)acetate (Intermediate 3) and 2-bromopyridine (Acros), the title compound was obtained as a beige powder after purification by precipitation in acetonitrile.

Sources & evidence

ORD record: ord-1e88b9e81d1c4beabe02ebb71ef037bd
Source dataset: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08273769B2

Reaction notes

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