HCID 58522072, compound → HCID 46866481, compound

HRID 2390365Notes

Reaction equation

HRID 2390365 reaction equation
C([O:5][C:6](=[O:34])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[C:16]#[C:17][C:18]1[CH:23]=[C:22]([S:24]([N:27]([CH2:29][CH:30]([CH3:32])[CH3:31])[CH3:28])(=[O:26])=[O:25])[CH:21]=[CH:20][C:19]=1[CH3:33])(C)(C)C>CCCCC.C(OCC)C>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:6]([OH:34])=[O:5])=[C:10]([C:16]#[C:17][C:18]2[CH:23]=[C:22]([S:24]([N:27]([CH2:29][CH:30]([CH3:31])[CH3:32])[CH3:28])(=[O:26])=[O:25])[CH:21]=[CH:20][C:19]=2[CH3:33])[CH:11]=1

Participants

3

Reactant 1

HCID 58522072HCID 58522072, compound2×

Product 1

HCID 46866481HCID 46866481, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 21877078Diethylether pentaneSolvent

Procedure

Following the general method as outlined in Example 15, starting from tert-butyl{4-chloro-2-[(5-{[isobutyl(methyl)amino]sulfonyl}-2-methylphenyl)ethynyl]phenoxy}acetate (Intermediate 160), the title compound was obtained as a beige solid in 77% yield after tituration in pentane/diethyl ether.

Sources & evidence

ORD record
ord-38afbaf8df53497081f8a314255576b6
Source dataset
uspto-grants-2012_09
Patent number
US08273769B2

Reaction notes

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