HCID 58522068, compound → HCID 46866482, compound

HRID 2390366Notes

Reaction equation

HRID 2390366 reaction equation
C([O:5][C:6](=[O:34])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[C:16]#[C:17][C:18]1[CH:23]=[C:22]([S:24]([N:27]([CH2:29][CH2:30][CH2:31][CH3:32])[CH3:28])(=[O:26])=[O:25])[CH:21]=[CH:20][C:19]=1[CH3:33])(C)(C)C>C(OCC)C.CCCCC>[CH2:29]([N:27]([CH3:28])[S:24]([C:22]1[CH:21]=[CH:20][C:19]([CH3:33])=[C:18]([C:17]#[C:16][C:10]2[CH:11]=[C:12]([Cl:15])[CH:13]=[CH:14][C:9]=2[O:8][CH2:7][C:6]([OH:34])=[O:5])[CH:23]=1)(=[O:25])=[O:26])[CH2:30][CH2:31][CH3:32]

Participants

3

Reactant 1

HCID 58522068HCID 58522068, compound2×

Product 1

HCID 46866482HCID 46866482, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 21877078Diethylether pentaneSolvent

Procedure

Following the general method as outlined in Example 15, starting from tert-butyl{2-[(5-{[butyl(methyl)amino]sulfonyl}-2-methylphenyl)ethynyl]-4-chlorophenoxy}acetate (Intermediate 161), the title compound was obtained as a beige solid in 96% yield after trituration in diethyl ether/pentane.

Sources & evidence

ORD record
ord-a05e6c64d6ce46c2aaef1ccd872664a5
Source dataset
uspto-grants-2012_09
Patent number
US08273769B2

Reaction notes

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