1-Ethynyl-3-(propylsulfonyl)benzene → HCID 46865086, compound

HRID 2390367Notes

Reaction equation

HRID 2390367 reaction equation
C([O:5][C:6](=[O:22])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:11][C:10]=1Br)(C)(C)C.[C:23]([C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([S:31]([CH2:34][CH2:35][CH3:36])(=[O:33])=[O:32])[CH:26]=1)#[CH:24]>>[CH2:34]([S:31]([C:27]1[CH:26]=[C:25]([C:23]#[C:24][C:10]2[CH:11]=[C:12]([C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:13]=[CH:14][C:9]=2[O:8][CH2:7][C:6]([OH:5])=[O:22])[CH:30]=[CH:29][CH:28]=1)(=[O:33])=[O:32])[CH2:35][CH3:36]

Participants

3

Reactant 2

HCID 565942671-Ethynyl-3-(propylsulfonyl)benzene2×HCID 58522099HCID 58522099, compound2×

Product 1

HCID 46865086HCID 46865086, compound

Procedure

Following the general method as outlined in Example 37, starting from tert-butyl[(3-bromobiphenyl-4-yl)oxy]acetate (Intermediate 188) and 1-ethynyl-3-(propane-1-sulfonyl)-benzene (Intermediate 42), the title compound was obtained as a beige solid after purification by preparative HPLC.

Sources & evidence

ORD record
ord-f3fd2a43d7ad42859d998eb6c5b7bff9
Source dataset
uspto-grants-2012_09
Patent number
US08273769B2

Reaction notes

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