N-methyl-2-pyrrolidone → HCID 43089837, compound

HRID 2390490Notes

Reaction equation

HRID 2390490 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].CN1CCCC1=O.[CH:22]([NH2:26])([CH2:24][CH3:25])[CH3:23]>O>[CH:22]([NH:26][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13])([CH2:24][CH3:25])[CH3:23]

Participants

5

Reactant 3

HCID 13387N-methyl-2-pyrrolidoneHCID 24874Sec-ButylamineHCID 677784-Fluoro-3-nitrobenzotrifluoride

Product 1

HCID 43089837HCID 43089837, compoundYield 88.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a mixture of 1.05 g of 4-fluoro-3-nitro-benzo trifluoride and 10 ml of N-methylpyrrolidone was added 1.10 g of sec-butylamine under ice cool, and the mixture was heated up to room temperature and stirred for 1.5 hours. Into the reaction mixture was poured water, and the deposited solid was collected by filtration. This solid was washed with water, then, dried under reduced pressure to obtain 1.16 g of N-sec-butyl-2-nitro-4-trifluoromethylaniline.

Workup

  1. temperaturecool
  2. filtrationthe deposited solid was collected by filtration
  3. washThis solid was washed with water
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-8a38d8e63bfd4428a84638ded2824d71
Source dataset
uspto-grants-2012_09
Patent number
US08273764B2

Reaction notes

Loading…