反应详情

A solution of NaOH (1.769 g, 44.23 mmol) in water (20.0 mL) was added to a stirred solution of ethyl 2-(pivaloyloxymethyl)thiazole-4-carboxylate (2.4 g, 8.85 mmol) in a mixture of THF (20 mL) and MeOH (10.0 mL), and the reaction stirred for 72 h. Acidified with 2M HCl (10 mL) and evaporated in vacuo to afford crude 2-(hydroxymethyl)thiazole-4-carboxylic acid as a white solid. Purified by reverse phase chromatography with MeCN/aqTFA as eluent to afford the sub-title compound as a white solid. Yield: 1.4 g

1. customAcidified with 2M HCl (10 mL) and evaporated in vacuo
2. customto afford crude 2-(hydroxymethyl)thiazole-4-carboxylic acid as a white solid
3. customPurified by reverse phase chromatography with MeCN/aqTFA as eluent